iLIR v1.0 WWW Server: RESULTS PAGE

Submitted 1 sequence
>sp|P22681|CBL_HUMAN E3 ubiquitin-protein ligase CBL OS=Homo sapiens GN=CBL PE=1 SV=2

{"length":"906","regions":[{
startStyle: "straight", endStyle: "straight",
start: 8, end: 24, text: "LCR", colour: "#86bcff",
"metadata":{ database: "INTRINSIC", type: "low_complexity_region",
description: "LCR", start: 8, end: 24}
},
{
startStyle: "curved", endStyle: "curved",
start: 47, end: 176, text: "Pfam:Cbl_N", colour: "#ff8800",
"metadata":{ database: "PFAM", type: "Pfam:Cbl_N",
description: "Pfam:Cbl_N", start: 47, end: 176}
},
{
startStyle: "curved", endStyle: "curved",
start: 178, end: 262, text: "Pfam:Cbl_N2", colour: "#ff8800",
"metadata":{ database: "PFAM", type: "Pfam:Cbl_N2",
description: "Pfam:Cbl_N2", start: 178, end: 262}
},
{
startStyle: "curved", endStyle: "curved",
start: 264, end: 349, text: "Pfam:Cbl_N3", colour: "#ff8800",
"metadata":{ database: "PFAM", type: "Pfam:Cbl_N3",
description: "Pfam:Cbl_N3", start: 264, end: 349}
},
{
startStyle: "curved", endStyle: "curved",
start: 381, end: 419, text: "RING", colour: "#ff8800",
"metadata":{ database: "SMART", type: "RING",
description: "RING", start: 381, end: 419}
},
{
startStyle: "straight", endStyle: "straight",
start: 456, end: 465, text: "LCR", colour: "#86bcff",
"metadata":{ database: "INTRINSIC", type: "low_complexity_region",
description: "LCR", start: 456, end: 465}
},
{
startStyle: "straight", endStyle: "straight",
start: 493, end: 504, text: "LCR", colour: "#86bcff",
"metadata":{ database: "INTRINSIC", type: "low_complexity_region",
description: "LCR", start: 493, end: 504}
},
{
startStyle: "straight", endStyle: "straight",
start: 532, end: 551, text: "LCR", colour: "#86bcff",
"metadata":{ database: "INTRINSIC", type: "low_complexity_region",
description: "LCR", start: 532, end: 551}
},
{
startStyle: "curved", endStyle: "curved",
start: 857, end: 894, text: "UBA", colour: "#00ff00",
"metadata":{ database: "SMART", type: "UBA",
description: "UBA", start: 857, end: 894}
},
{
startStyle: "straight", endStyle: "straight",
start: 90, end: 95, text: "xLIR", colour: "#ff00ff",
lineStyle: "bold", v_align: "top", label: "xLIR",
"metadata":{ database: "xLIR web server", type: "xLIR-motif",
description: "xLIR-motif:DTYQHL", start: 90, end: 95}
},
{
startStyle: "straight", endStyle: "straight",
start: 272, end: 277, text: "xLIR", colour: "#ff00ff",
lineStyle: "bold", v_align: "top", label: "xLIR",
"metadata":{ database: "xLIR web server", type: "xLIR-motif",
description: "xLIR-motif:LTYDEV", start: 272, end: 277}
},
{
startStyle: "straight", endStyle: "straight",
start: 800, end: 805, text: "xLIR", colour: "#ff00ff",
lineStyle: "bold", v_align: "top", label: "xLIR",
"metadata":{ database: "xLIR web server", type: "xLIR-motif",
description: "xLIR-motif:FGWLSL", start: 800, end: 805}
},
{
startStyle: "straight", endStyle: "straight",
start: 893, end: 898, text: "xLIR", colour: "#ff00ff",
lineStyle: "bold", v_align: "top", label: "xLIR",
"metadata":{ database: "xLIR web server", type: "xLIR-motif",
description: "xLIR-motif:REFVSI", start: 893, end: 898}
},
]
}

xLIR motifs are displayed as magenta rectangles in the domain architecture graphic

MOTIF	START	END	LIR sequence	PSSM score	Similar LIRs	In PDB	Anchor
xLIR	90	95	DTYQHL	14 (5.7e-02)		[+/-] 2Y1N_A,C 2Y1M_A,B,C,D,E,F 2Y1N_A,C 2Y1M_A,B,C,D,E,F 3BUX_B,D 3BUW_B,D 3BUO_B,D 3BUN_B 3BUM_B 1YVH_A 4GPL_B 2CBL_A 1B47_A,B,C 3PFV_A,B 4A4C_A 3OP0_A,B 3VRR_A 3VRQ_A,B 3VRP_A 3VRO_A 3VRN_A 4A4B_A 1FBV_A 3ZNI_A,E,I,M 3VGO_A,B,C 3PLF_B,D 3OB2_B 3OB1_B	No
xLIR	272	277	LTYDEV	11 (1.5e-01)	ATG4B_HUMAN 6-11 (4)	[+/-] 2Y1N_A,C 2Y1M_A,B,C,D,E,F 2Y1N_A,C 2Y1M_A,B,C,D,E,F 3BUX_B,D 3BUW_B,D 3BUO_B,D 3BUN_B 3BUM_B 1YVH_A 4GPL_B 2CBL_A 1B47_A,B,C 3PFV_A,B 4A4C_A 3OP0_A,B 3VRR_A 3VRQ_A,B 3VRP_A 3VRO_A 3VRN_A 4A4B_A 1FBV_A 3ZNI_A,E,I,M 3VGO_A,B,C 3PLF_B,D 3OB2_B 3OB1_B	No
xLIR	800	805	FGWLSL	18 (1.6e-02)	CBL_HUMAN 800-805 (6)		Yes
xLIR	893	898	REFVSI	13 (7.9e-02)		[+/-] 2JUJ_A 2OO9_A,B,C 2JUJ_A 2OO9_A,B,C 2D9S_A,B 2DO6_A,B 2JNH_A 2OOB_A 2OOA_A,B	Yes

[+/-] Show/Hide Detailed ANCHOR results

DOMAIN	START	END	STATUS
ANCHOR01	1	7	hidden
ANCHOR02	22	33	hidden
ANCHOR03	56	71	hidden
ANCHOR04	463	478	hidden
ANCHOR05	484	540	hidden
ANCHOR06	552	558	hidden
ANCHOR07	565	602	hidden
ANCHOR08	614	626	hidden
ANCHOR09	635	659	hidden
ANCHOR10	668	684	hidden
ANCHOR11	718	745	hidden
ANCHOR12	747	759	hidden
ANCHOR13	776	808	hidden
ANCHOR14	836	842	hidden
ANCHOR15	863	881	hidden
ANCHOR16	891	896	hidden

[+/-] Show/Hide Detailed SMART results

DOMAIN	START	END	E-VALUE	TYPE	STATUS
low_complexity_region	8	24	0	INTRINSIC	visible\|OK
low_complexity_region	35	48	0	INTRINSIC	hidden\|overlap
Pfam:Cbl_N	47	176	3.4e-76	PFAM	visible\|OK
Pfam:Cbl_N2	178	262	1.8e-48	PFAM	visible\|OK
Pfam:Cbl_N3	264	349	5.9e-56	PFAM	visible\|OK
SMART:RING	381	419	1.0e-07	SMART	visible\|OK
Pfam:zf-C3HC4	381	419	6.6e-11	PFAM	hidden\|overlap
low_complexity_region	456	465	0	INTRINSIC	visible\|OK
low_complexity_region	493	504	0	INTRINSIC	visible\|OK
low_complexity_region	532	551	0	INTRINSIC	visible\|OK
low_complexity_region	837	859	0	INTRINSIC	hidden\|overlap
SMART:UBA	857	894	1.5e-07	SMART	visible\|OK
Pfam:UBA	857	892	6.3e-08	PFAM	hidden\|overlap