GeneProteinUniprot ACCOrganismLIR start positionLIR sequencePSSMiLIRdbVerified LIR motifReferences
Components of the core autophagy machinery
ATG1 Serine/threonine-protein kinase ATG1P53104S. cerevisiae427REYVVV14yesyesNakatogaya et al. 2012, Kraft et al. 2012
ATG1BAutophagy-related 1, isoform BQ8MQJ7 D. melanogaster391DDFVLV N/AnoyesAlemu et al. 2012
ATG13 Autophagy-related protein 13O75143H. sapiens442DDFVMI20yesyesAlemu et al. 2012
ATG16L1 Autophagy-related protein 16-1Q676U5H. sapiens164DEYDAL16yesnoBehrends et al. 2010
ATG3Autophagy-related protein 3P40344 S. cerevisiae270WEDL N/AnoyesYamaguchi et al. 2012
PfATG3Autophagy-related protein 3C0H519P. falciparum105WLLPN/AnoyesHain et al. 2012
ATG4BCysteine protease ATG4BQ9Y4P1 H. sapiens8YDTL N/AnoyesSatoo et al. 2009, Behrends et al. 2010, Li et al. 2011
ULK1 Serine/threonine-protein kinase ULK1O75385H. sapiens355DDFVMV19yesyesAlemu et al. 2012, Kraft et al. 2012
ULK2 Serine/threonine-protein kinase ULK2Q8IYT8H. sapiens351DDFVLV17yesyesAlemu et al. 2012
RB1CC1/FIP200RB1-inducible coiled-coil protein 1Q8TDY2H. sapiens700FDFETI17yesyesAlemu et al. 2012
Receptors for selective autophagy
Alfy/WDFY3WD repeat and FYVE domain-containing protein 3Q8IZQ1H. sapiens3344DGFIFV13yesyesLystad et al. 2014
ATG19 Autophagy-related protein 19P35193 S. cerevisiae412WEEL N/AnoyesNoda et al. 2008
ATG32 Autophagy-related protein 32P40458S. cerevisiae84GSWQAI17yesyesOkamoto et al. 2009, Kondo-Okomoto et al. 2012
ATG34 Autophagy-related protein 34Q12292 S. cerevisiae409WEEI N/AnoyesSuzuki et al. 2010
BNIP3BCL2/adenovirus E1B 19 kDa protein-interacting protein 3Q12983H. sapiens16GSWVEL19yesyesHanna et al. 2012, Zhu et al. 2013
BNIP3L/NixBCL2/adenovirus E1B 19 kDa protein-interacting protein 3-likeO60238H. sapiens34SSWVEL20yesyesSchwarten et al. 2009, Novak et al. 2010
CBL E3 ubiquitin-protein ligase CBLP22681H. sapiens800FGWLSL18yesyesSandilands et al. 2012
FUNDC1 FUN14 domain-containing protein 1Q8IVP5 H. sapiens18YEVL N/AnoyesLiu et al. 2012
NBR1 Next to BRCA1 gene 1 proteinQ14596H. sapiens561LSFELL10yesnoKirkin et al. 2009, Behrends et al. 2010
730EDYIII17yesyes-do-
AtNBR1 Next to BRCA1 gene 1 proteinQ9SB64A. thaliana661WDPIN/AnoyesSvenning et al. 2011
NCOA4Q13772H. sapiens484DSFQVI14yesnoMancias et al. 2014, Bellelli et al. 2016
NDP52Q13137H. sapiens134LVVN/AnoyesThurston et al. 2009, von Muhlinen et al. 2012
OPTN OptineurinQ96CV9H. sapiens176DSFVEI15yesyesWild et al. 2011
SQSTM1/p62 Sequestosome-1Q13501H. sapiens336DDWTHL24yesyesPankiv et al. 2007, Ichimura et al. 2008
Stbd1Starch-binding domain-containing protein 1O95210 H. sapiens203WEMV N/AnoyesBehrends et al. 2010, Jiang et al. 2011
TAX1BP1 Tax1-binding protein 1Q86VP1H. sapiens139DMLVVN/AnoyesNewman et al. 2012
514ADFDIV15yesno-do-
Proteins associated with the autophagosome and other vesicles
Clathrin HCClathrin heavy chain 1Q00610 H. sapiens514WIFL N/AnoyesMohrlüder et al. 2007
CALR CalreticulinP27797H. sapiens198DDWDFL26yesyesMohrlüder et al. 2007
FYCO1FYVE and coiled-coil domain-containing protein 1Q9BQS8H. sapiens644ADYQAL15yesnoPankiv et al. 2010, Alemu et al. 2012
1278AVFDII8yesyes-do-
MAPK15Mitogen-activated protein kinase 15Q8TD08H. sapiens338RVYQMI10yesyesColeccia et al. 2012
TBC1D2BTBC1 domain family member 2BQ9UPU7H. sapiens252EEWELL20yesnoBehrends et al. 2010
TBC1D5TBC1 domain family member 5Q92609H. sapiens58WEEL N/AnoyesPopovic et al. 2012
713DDFILI17yesno-do-
785SGFTIV11yesyes-do-
TBC1D25 TBC1 domain family member 25Q3MII6 H. sapiens136WDII N/AnoyesItoh et al. 2011
TP53INP1Tumor protein p53-inducible nuclear protein 1Q96A56H. sapiens29DEWILV20yesyesSeilier et al. 2012, Sancho et al. 2012
Proteins involved in the postranslational modification of Atg8 proteins
STK3Serine/threonine-protein kinase 3Q13188H. sapiens435GDFDFL16yesnoBehrends et al. 2010, Wilkinson et al. 2015
STK4Serine/threonine-protein kinase 4Q13043H. sapiens431GDYEFL17yesnoBehrends et al. 2010, Wilkinson et al. 2015
TP53INP2/DOR Tumor protein p53-inducible nuclear protein 2Q8IXH6H. sapiens33DGWLII21yesyesNowak et al. 2009, Sancho et al. 2012
Other
b-catenineCatenin beta-1P35222 H. sapiens504WPLI N/AnoyesPetherick et al. 2013
Dvl2Dishevelled-2O14641 H. sapiens444WLKI N/AnoyesGao et al. 2010
NCOA7Nuclear receptor coactivator 7Q8NI08H. sapiens414DDFVDL18yesnoBehrends et al. 2010
NEDD4E3 ubiquitin-protein ligase NEDD4P46934H. sapiens589PGWVVL19yesnoBehrends et al. 2010
Spred-2Sprouty-related, EVH1 domain-containing protein 2Q7Z698H. sapiens370WMALN/AnoyesJiang et al. 2016