iLIR Autophagy Database

Gene

Protein

Uniprot ACC

Organism

LIR start position

LIR sequence

PSSM

iLIRdb

Verified LIR motif

References

Components of the core autophagy machinery

ATG1	Serine/threonine-protein kinase ATG1	P53104	S. cerevisiae	427	REYVVV	14	yes	yes	Nakatogaya et al. 2012, Kraft et al. 2012
ATG1B	Autophagy-related 1, isoform B	Q8MQJ7	D. melanogaster	391	DDFVLV	N/A	no	yes	Alemu et al. 2012
ATG13	Autophagy-related protein 13	O75143	H. sapiens	442	DDFVMI	20	yes	yes	Alemu et al. 2012
ATG16L1	Autophagy-related protein 16-1	Q676U5	H. sapiens	164	DEYDAL	16	yes	no	Behrends et al. 2010
ATG3	Autophagy-related protein 3	P40344	S. cerevisiae	270	WEDL	N/A	no	yes	Yamaguchi et al. 2012
PfATG3	Autophagy-related protein 3	C0H519	P. falciparum	105	WLLP	N/A	no	yes	Hain et al. 2012
ATG4B	Cysteine protease ATG4B	Q9Y4P1	H. sapiens	8	YDTL	N/A	no	yes	Satoo et al. 2009, Behrends et al. 2010, Li et al. 2011
ULK1	Serine/threonine-protein kinase ULK1	O75385	H. sapiens	355	DDFVMV	19	yes	yes	Alemu et al. 2012, Kraft et al. 2012
ULK2	Serine/threonine-protein kinase ULK2	Q8IYT8	H. sapiens	351	DDFVLV	17	yes	yes	Alemu et al. 2012
RB1CC1/FIP200	RB1-inducible coiled-coil protein 1	Q8TDY2	H. sapiens	700	FDFETI	17	yes	yes	Alemu et al. 2012

Receptors for selective autophagy

Alfy/WDFY3	WD repeat and FYVE domain-containing protein 3	Q8IZQ1	H. sapiens	3344	DGFIFV	13	yes	yes	Lystad et al. 2014
ATG19	Autophagy-related protein 19	P35193	S. cerevisiae	412	WEEL	N/A	no	yes	Noda et al. 2008
ATG32	Autophagy-related protein 32	P40458	S. cerevisiae	84	GSWQAI	17	yes	yes	Okamoto et al. 2009, Kondo-Okomoto et al. 2012
ATG34	Autophagy-related protein 34	Q12292	S. cerevisiae	409	WEEI	N/A	no	yes	Suzuki et al. 2010
BNIP3	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3	Q12983	H. sapiens	16	GSWVEL	19	yes	yes	Hanna et al. 2012, Zhu et al. 2013
BNIP3L/Nix	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like	O60238	H. sapiens	34	SSWVEL	20	yes	yes	Schwarten et al. 2009, Novak et al. 2010
CBL	E3 ubiquitin-protein ligase CBL	P22681	H. sapiens	800	FGWLSL	18	yes	yes	Sandilands et al. 2012
FUNDC1	FUN14 domain-containing protein 1	Q8IVP5	H. sapiens	18	YEVL	N/A	no	yes	Liu et al. 2012
NBR1	Next to BRCA1 gene 1 protein	Q14596	H. sapiens	561	LSFELL	10	yes	no	Kirkin et al. 2009, Behrends et al. 2010
				730	EDYIII	17	yes	yes	-do-
AtNBR1	Next to BRCA1 gene 1 protein	Q9SB64	A. thaliana	661	WDPI	N/A	no	yes	Svenning et al. 2011
NCOA4		Q13772	H. sapiens	484	DSFQVI	14	yes	no	Mancias et al. 2014, Bellelli et al. 2016
NDP52		Q13137	H. sapiens	134	LVV	N/A	no	yes	Thurston et al. 2009, von Muhlinen et al. 2012
OPTN	Optineurin	Q96CV9	H. sapiens	176	DSFVEI	15	yes	yes	Wild et al. 2011
SQSTM1/p62	Sequestosome-1	Q13501	H. sapiens	336	DDWTHL	24	yes	yes	Pankiv et al. 2007, Ichimura et al. 2008
Stbd1	Starch-binding domain-containing protein 1	O95210	H. sapiens	203	WEMV	N/A	no	yes	Behrends et al. 2010, Jiang et al. 2011
TAX1BP1	Tax1-binding protein 1	Q86VP1	H. sapiens	139	DMLVV	N/A	no	yes	Newman et al. 2012
				514	ADFDIV	15	yes	no	-do-

Proteins associated with the autophagosome and other vesicles

Clathrin HC	Clathrin heavy chain 1	Q00610	H. sapiens	514	WIFL	N/A	no	yes	Mohrlüder et al. 2007
CALR	Calreticulin	P27797	H. sapiens	198	DDWDFL	26	yes	yes	Mohrlüder et al. 2007
FYCO1	FYVE and coiled-coil domain-containing protein 1	Q9BQS8	H. sapiens	644	ADYQAL	15	yes	no	Pankiv et al. 2010, Alemu et al. 2012
				1278	AVFDII	8	yes	yes	-do-
MAPK15	Mitogen-activated protein kinase 15	Q8TD08	H. sapiens	338	RVYQMI	10	yes	yes	Coleccia et al. 2012
TBC1D2B	TBC1 domain family member 2B	Q9UPU7	H. sapiens	252	EEWELL	20	yes	no	Behrends et al. 2010
TBC1D5	TBC1 domain family member 5	Q92609	H. sapiens	58	WEEL	N/A	no	yes	Popovic et al. 2012
				713	DDFILI	17	yes	no	-do-
				785	SGFTIV	11	yes	yes	-do-
TBC1D25	TBC1 domain family member 25	Q3MII6	H. sapiens	136	WDII	N/A	no	yes	Itoh et al. 2011
TP53INP1	Tumor protein p53-inducible nuclear protein 1	Q96A56	H. sapiens	29	DEWILV	20	yes	yes	Seilier et al. 2012, Sancho et al. 2012

Proteins involved in the postranslational modification of Atg8 proteins

STK3	Serine/threonine-protein kinase 3	Q13188	H. sapiens	435	GDFDFL	16	yes	no	Behrends et al. 2010, Wilkinson et al. 2015
STK4	Serine/threonine-protein kinase 4	Q13043	H. sapiens	431	GDYEFL	17	yes	no	Behrends et al. 2010, Wilkinson et al. 2015
TP53INP2/DOR	Tumor protein p53-inducible nuclear protein 2	Q8IXH6	H. sapiens	33	DGWLII	21	yes	yes	Nowak et al. 2009, Sancho et al. 2012

Other

b-catenine	Catenin beta-1	P35222	H. sapiens	504	WPLI	N/A	no	yes	Petherick et al. 2013
Dvl2	Dishevelled-2	O14641	H. sapiens	444	WLKI	N/A	no	yes	Gao et al. 2010
NCOA7	Nuclear receptor coactivator 7	Q8NI08	H. sapiens	414	DDFVDL	18	yes	no	Behrends et al. 2010
NEDD4	E3 ubiquitin-protein ligase NEDD4	P46934	H. sapiens	589	PGWVVL	19	yes	no	Behrends et al. 2010
Spred-2	Sprouty-related, EVH1 domain-containing protein 2	Q7Z698	H. sapiens	370	WMAL	N/A	no	yes	Jiang et al. 2016